BioNTech, once celebrated for its COVID-19 vaccines, is grappling with falling demand, restructuring and the departure of its founders. Can its ambitious cancer trials turn it from a one-hit wonder into a biotech giant?
BioNTech, which had spent over a decade developing mRNA for cancer with little commercial interest, partnered with Pfizer to roll out its Comirnaty coronavirus vaccine in record time, propelling the company and its founders to global fame.
Today, however, the Mainz-based biotech firm is facing a harsh reckoning.
The company that once rolled out billions of vaccine doses, credited with averting millions of COVID deaths and allowing locked-down economies to reopen, now risks being remembered as a one-trick pony.
Why is BioNTech in trouble?
Financial analysts say that BioNTech's problems stem from the predictable end of a temporary COVID windfall, which provided tens of billions of euros in revenue since late 2020.
This, combined with the high-risk nature of research and development in the biotechnology sector and Germany's current economic woes — high labor and energy costs along with red tape — has revealed how risky it is to rely on a single blockbuster product.
Demand for BioNTech's COVID vaccine Comirnaty evaporated faster than expected, with first-quarter 2026 revenues dropping to €118 million, down 35% from the same quarter last year.
Announcing the results, the firm wrote that it "anticipates lower COVID-19 vaccine revenues compared to 2025, driven by declines in both the European and United States markets." Analysts say the company built too much production capacity during the boom and now faces idle plants. As a result, BioNTech says it will shift all COVID manufacturing to Pfizer.
The company also benefited from hundreds of millions of euros in German state support, both for its cancer research and to speed up its vaccine program.
Bitterness lingers after CureVac takeover The firm also courted controversy over the $1.25-billion (€1.06 billion) acquisition of rival CureVac in December 2025.
CureVac had developed its own COVID vaccine candidate, which showed low efficacy and was abandoned. But that did not stop it from suing BioNTech and Pfizer in 2022, claiming the Comirnaty vaccine infringed several of its mRNA patents.
By buying its rival — and its patents — BioNTech was able to end all litigation and avoid potential multibillion‑euro damages.
Tübingen's Mayor Boris Palmer accused the firm of adopting a "buy first, then kill" strategy, adding that the plant closure was a "heavy blow" for the "many highly qualified employees who have carried CureVac for years." The move was labeled a "planned slash-and-burn approach" by the IG BCE trade union, which lambasted what it said were "short-term financial reasons ... that would damage the resilience of Germany's biotech hub." The local chamber of commerce (IHK Reutlingen) warned in a statement that "technological know-how in the form of clever minds, patents and research and development results will be lost" through the plant closure.
Can BioNTech thrive without founders?
Sahin and Türeci, who in March announced their departures by the end of the year to launch an ambitious new biotech venture, were not just the founders of BioNTech, they were the driving force behind the company's success.
In a sign of their pivotal role, shares in BioNTech plunged by around 18% upon the announcement, with Leerink Partners, a Boston-based investment bank focused on healthcare, asking whether the firm can maintain its innovative edge without them.
"Can the company effectively iterate and expand their approach without their founders' insight on translational and clinical data?" Leerink analysts questioned in a research note.
How an mRNA vaccine could transform cancer care To view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video BioNTech is now shifting focus to late-stage cancer treatments. This includes new therapies being developed with Bristol Myers Squibb for breast, lung and other cancers.
In its latest quarterly update, the company said it expects to have 15 make-or-break Phase 3 cancer trials running by the end of the year.
Outgoing CEO Sahin said BioNTech will "continue to focus on accelerating our key strategic programs as we remain steadfast in our vision to translate our science into survival for patients living with cancer." By handing COVID vaccine production to Pfizer and closing some plants, BioNTech aims to save around €500 million per year by 2029.
The company says it will keep a small stake in the new startup being launched by its founders, which will work on next-generation mRNA technology.
Edited by: Tim Rooks Advertisement
